In 1990, Jamie Lee Curtis and her father Tony helped finance the rebuilding of the Great Synagogue in Budapest, Hungary, which had suffered damage during World War II. It’s the largest synagogue in Europe, and was originally built in 1859.

In 2003, She was the guest of honour at the 11th annual gala and fundraiser for Women in Recovery. Based in Venice, California, it’s a non-profit organization that offers a live-in, twelve-step program of rehabilitation for women in need.

Jamie Lee Curtis is also involved in the work of the Children Affected by AIDS Foundation, serving as the annual host for the organization’s “Dream Halloween” event in Los Angeles that takes place every October. She has a leadership role for the Children’s Hospital of Los Angeles, and frequently partakes in charity fundraisers for the hospital. Her first and only horror movie convention appearance in 2012 took place solely to raise money for the hospital to build a new wing.

During California’s 2008 general election, Curtis appeared in the “Yes on Prop 3” television advertisements, and advocated against Proposition 8, which would ban same-sex marriage in the state.

In March 2012, she was featured with Martin Sheen and Brad Pitt in a performance of Dustin Lance Black’s play 8, which was a staged reenactment of the federal trial that overturned California’s Prop 8 ban on same-sex marriage. She portrayed Sandy Stier. The production was held at the Wilshire Ebell Theatre and broadcast on YouTube to raise money for the American Foundation for Equal Rights.

In June 2016, the Human Rights Campaign released a video in tribute to the victims of the 2016 Pulse nightclub shooting in Orlando; in the video, Curtis and others told the stories of the people killed there.